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Generic Name: Vedolizumab

Medication Guide: PDF Download

Administration Guide: Online Guide & Video

Basic Step-by-Step:   


**ALWAYS establish patent IV access and flush PRIOR to mixing medication**


  • Obtain a clear/clean space to prepare the Entyvio.

  • Be sure all the necessary supplies are available to complete infusion from beginning to end.  You will need IV start supplies, syringe, needle, and sterile water for reconstitution, 250ml bag of NS, tubing (gravity tubing or pump tubing if using a pump).

  • Entyvio comes as a powder in a glass vial. Reconstitute powder by adding 4.8ml of sterile water to the vial. 

  • Direct the sterile water stream to the wall of the vial to avoid excessive foaming.

  • Gently swirl to mix.  Do not shake. Allow powder to fully dissolve.

  • Withdraw the 5ml reconstituted Entyvio solution from the vial and add to the bag of Normal Saline.

  • Gently mix the bag.


  1. Take baseline vitals and document basic assessment.

  2. Spike the bag of Entyvio & prime line.

  3. Infuse Entyvio over 30 minutes or per order.

  4. Record vitals 15 minutes after infusion start and 5 minutes post infusion.

  5. Record lot numbers and expiration dates for vials used.

  6. Disconnect patient, flush line, and remove IV. Place pressure bandage at site. 

  7. Clean and dispose of used supplies.

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