TEPEZZA

Generic Name: Teprotumumab-trbw

Medication Guide: PDF Download

Administration Guide: PDF Download

Basic Step-by-Step:

**ALWAYS establish patent IV access and flush PRIOR to mixing medication**

MIXING

Tepezza is supplied as a powder in a glass vial.
Obtain a clear/clean space to prepare the medication under aseptic technique.
Be sure all the necessary supplies are available to complete infusion from beginning to end.
You will need:
- IV start/ port access supplies
- Tepezza vials
- sterile syringe and needle
- Sterile Water for reconstitution
- Normal Saline bag for dilution
- tubing (gravity tubing or pump tubing if using a pump)
- in-line filters with 0.2 micron pore size is optional for this medication
Using appropriate aseptic technique, reconstitute each vial of Tepezza by adding 10ml of Sterile Water to each vial.
- Direct the stream of liquid to the side of the vial.
- Rotate the vial gently in a swirling motion until the contents are completely dissolved.
- DO NOT Shake. Solution should be colorless or slightly brown, clear to opalescent with no particulate matter.
From the bag of NS, remove the volume of saline equal to the amount of reconstituted Tepezza solution to be placed into the bag.
Inject medication into the bag of Normal Saline.
- Gently mix the contents. DO NOT shake.
Spike the IV bag with the proper pump or gravity tubing

ADMINISTRATION

Take and document baseline vitals. Document basic assessment.
Infuse Tepezza (1st & 2nd dose) over 90 minutes or per order.
1. Subsequent infusions can run over 60 minutes if patient tolerates
Take and document vitals at 30 and 60 minutes, then 5 minutes post-infusion.
Document lot numbers and expiration dates for all vials used.
Disconnect patient, flush line, and remove IV, placing a pressure bandage at site.
Clean and dispose of used supplies.