KRYSTEXXA (IV)

pegloticase

ALWAYS establish patent IV access and flush PRIOR to mixing medication

ALWAYS establish IV access prior to mixing any meds

ALWAYS make sure you have everything you need to complete infusion before you begin

ALWAYS confirm your medication dose against the medication label and orders

ALWAYS reach out to us first (not the Pharmacy) with any questions

NEVER tell a Pt you have not given a particular medication before

Obtain a clear/clean space to prepare the KRYSTEXXA
Kyrstexxa comes in either a ready- to-use vial or a to-be-diluted vial.
Ready-to-use Vial:
- You will need: IV start kit, infusion pump and tubing, vented spike
- Spike the vial using a vented spike and infuse straight from the vial
To-be-diluted Vial:
- To-be-diluted Vial: IV start kit, needle and syringe to draw up medication, 250 ml bag of 0.9% Sodium Chloride Injection, USP or 0.45% Sodium Chloride Injection, USP; gravity flow tubing or IV tubing and pump
- Draw up the appropriate amount and inject into the 250 ml bag of fluids
- Gently invert the infusion bag to ensure mixing; do not shake

Take baseline vitals and document basic assessment
Infuse over 120 minutes
- Ready-to-use Vial: Rate will be 25 ml/hr
- To-be-diluted Vial: Rate will be 125 ml/hr
Monitor patient for any adverse reactions
Record vitals every 15 minutes after infusion start, AND 5-10 minutes post infusion
Record lot numbers and expiration dates for vials used
After the entire contents of the vial have been administered, flush the IV line with sodium chloride injection to ensure delivery of the required dose
Disconnect patient, flush line, and remove IV
- Place pressure bandage at site
Clean and dispose of used supplies

HCP Website: Krystexxa HCP

Prescribing Info: Krystexxa PI