Pharmacy specific orders / instructions always supersede the Agency guidance provided below. If in doubt, do not guess, call our office, or tag @TeamHelp-CareCoordination(Best Tag) and ask for Clinical Support.
ALWAYS establish IV access prior to mixing any meds
ALWAYS make sure you have everything you need to complete infusion before you begin
ALWAYS confirm your medication dose against the medication label and orders
ALWAYS reach out to us first (not the Pharmacy) with any questions
NEVER tell a Pt you have not given a particular medication before
MIXING
NOTE: All patients must first receive at least one full dose of RITUXIMAB (IV) without experiencing severe adverse reactions before starting treatment with RITUXAN HYCELA due to the higher risk of hypersensitivity and other acute reactions during the first infusion
NOTE: During treatment with RITUXAN HYCELA, do not administer other medications for subcutaneous use at the same sites as RITUXAN HYCELA
Obtain a clear/clean space to prepare the
Be sure all the necessary supplies are available to complete infusion from beginning to end. You will need:
Medication, 20 ml syringe, 25-30 gauge needle of any length, 25-30 gauge needle 1/2” – 5/8”
Use a sterile needle and syringe to prepare RITUXAN HYCELA.
Using a sterile 20 mL syringe and a sterile 25-30 gauge needle of any length, withdraw the required volume from the vial
Change the needle to a 1/2” to 5/8” long, narrow gauge needle (e.g., 25–30 gauge) immediately prior to subcutaneous administration to avoid needle clogging.
Visually inspect for particulate matter and discoloration prior to administration.
RITUXAN HYCELA should be a clear to opalescent and colorless to yellowish liquid. Do not use if particulates or discoloration is present
ADMINISTRATION
Take baseline vitals and document basic assessment
Inject RITUXAN HYCELA into subcutaneous tissue of abdomen over approximately 5–7 minutes
Never inject into areas where skin is red, bruised, tender or hard, or areas where there are moles or scars.
Inject slowly:
Inject 11.7 mL of RITUXAN HYCELA 1,400 mg/23,400 Units vial (1,400 mg rituximab and 23,400 Units hyaluronidase human) subcutaneously into abdomen over approximately 5 minutes
Inject 13.4 mL of RITUXAN HYCELA 1,600 mg/26,800 Units vial (1,600 mg rituximab and 26,800 Units hyaluronidase human) subcutaneously into abdomen over approximately 7 minutes
If administration of RITUXAN HYCELA is interrupted, continue administering at the same site, or at a different site, but restricted to the abdomen
Monitor patient for any adverse reactions
Record vital signs at baseline AND 5-10 minutes post infusion
Record lot numbers and expiration dates for vials used
Observe patients for at least 15 minutes following RITUXAN HYCELA administration
Place bandage or gauze at site if needed
Clean and dispose of used supplies
ADDITIONAL INFO
HCP Website: Rituxanhycela HCP Prescribing Info: Rotuxan Hycela PI
Medication Guide: Rituxan Hycela Med Guide