**ALWAYS establish patent IV access and flush PRIOR to mixing medication**
Pharmacy specific orders / instructions always supersede the Agency guidance provided below. If in doubt, do not guess, call our office, or tag @TeamHelp-CareCoordination and ask for Clinical Support.
ALWAYSÂ establish IV access prior to mixing any meds
ALWAYSÂ make sure you have everything you need to complete infusion before you begin
ALWAYSÂ confirm your medication dose against the medication label and orders
ALWAYSÂ reach out to us first (not the Pharmacy) with any questions
NEVERÂ tell a Pt you have not given a particular medication before
MIXING
Obtain a clear/clean space to prepare the RUCONEST
Be sure all the necessary supplies are available to complete infusion from beginning to end
You will need sterile water, alcohol, syringe, needle to draw up and 23-gauge butterfly
Reconstitute each vial (2100 U) by adding 14 mL sterile Water for Injection per vial to obtain a solution of 150 U per mL
The reconstituted solution should be colorless, clear and free from visible particles
ADMINISTRATION
Take baseline vitals and document basic assessment
Administer the reconstituted solution at room temperature as a slow intravenous injection over approximately 5 minutes
May administer through a butterfly or a PIV
Appropriately trained patients may self-administer upon recognition of an HAE attack
Record vitals prior to infusion and 5-10 minutes post infusion
Record lot numbers and expiration dates for vials used
Disconnect patient, flush line, and remove IV. Place pressure bandage at site
Clean and dispose of used supplies
ADDITIONAL INFO
HCP Website:Â Ruconesthcp
Prescribing Info:  Ruconest Prescribing Info Â
Patient Brochure:Â Ruconest-Patient-Education-Brochure