**ALWAYS establish patent IV access and flush PRIOR to mixing medication**
Pharmacy specific orders / instructions always supersede the Agency guidance provided below. If in doubt, do not guess, call our office, or tag @TeamHelp-CareCoordination and ask for Clinical Support.
ALWAYSÂ establish IV access prior to mixing any meds
ALWAYSÂ make sure you have everything you need to complete infusion before you begin
ALWAYSÂ confirm your medication dose against the medication label and orders
ALWAYSÂ reach out to us first (not the Pharmacy) with any questions
NEVERÂ tell a Pt you have not given a particular medication before
MIXING
1. SKYRIZI vial for intravenous administration is intended for administration by a healthcare provider using aseptic technique.
2. Prior to intravenous administration, withdraw 10 mL of SKYRIZI solution from the vial and inject into an intravenous infusion bag or glass bottle containing 5% Dextrose Injection (600 mg/10 mL in 100 mL, or 250 mL, or 500 mL) for a final concentration of approximately 1.2 mg/mL to 6 mg/mL.
Discard any remaining solution in the vial.
3. Do not shake the vial or diluted solution in the infusion bag or glass bottle.
4. Allow the diluted SKYRIZI solution in the infusion bag or glass bottle to warm to room temperature (if stored refrigerated) prior to the start of the intravenous infusion
5. Infuse the diluted solution intravenously over a period of at least one hour. Complete the infusion within 8 hours of dilution.
6. Do not administer SKYRIZI diluted solution concomitantly in the same intravenous line with other medicinal products.
ADMINISTRATION
Take baseline vitals and document basic assessment.
Spike the bag of Skyrizi & prime line.
Infuse Skyrizi over 1 hour or per order.
Record vitals every 15 minutes after infusion start AND 5-10 minutes post infusion.
Record lot numbers and expiration dates for vials used.
Disconnect patient, flush line, and remove IV.
Place pressure bandage at site.Â
Clean and dispose of used supplies.