**ALWAYS establish patent IV access and flush PRIOR to mixing medication**
Pharmacy specific orders / instructions always supersede the Agency guidance provided below. If in doubt, do not guess, call our office, or tag @TeamHelp-CareCoordination and ask for Clinical Support.
ALWAYS establish IV access prior to mixing any meds
ALWAYS make sure you have everything you need to complete infusion before you begin
ALWAYS confirm your medication dose against the medication label and orders
ALWAYS reach out to us first (not the Pharmacy) with any questions
NEVER tell a Pt you have not given a particular medication before
MIXING
Soliris is supplied in liquid form in a glass vial.
Obtain a clear/clean space to prepare the medication.
Be sure all the necessary supplies are available to complete infusion from beginning to end. You will need IV start/ port access supplies, Soliris vials, sterile syringe and needle, 250ml bag of Normal Saline for dilution, tubing (gravity tubing or pump tubing if using a pump.)
Be careful when injecting the medication in the bag not to inadvertently puncture the bag.
Using appropriate aseptic technique, you will mix Soliris to a 1:1 ratio with the NS.
Soliris is prescribed in doses of:
600mg (2 vials = 60ml > dilute with 60ml of NS, or
900mg (3 vials = 90ml > dilute with 90ml of NS, or
1200mg (4 vials = 120ml > dilute with 120ml of NS
In most cases, the pharmacy sends a 250ml bag of NS. In some cases the pharmacy sends the appropriate amount of NS for dilution (they have already removed the excess amount).
If the pharmacy has not already, you will remove the excess amount of NS so that you are left with a volume equal to the Soliris dose/volume ordered.
Example: Pt is to receive 1200mg of Soliris. This will be 4 vials which yields a volume of 120ml. You will remove and discard 130ml of NS leaving 120ml of NS in the bag. Then draw up and inject 120ml of Soliris into the NS bag for a total volume of 240ml (120ml NS + 120ml Soliris).
Follow the above steps or adjust as needed for a 600mg (60ml) or 900mg (90ml) dose.
Gently invert the bag in order to distribute medication evenly. DO NOT SHAKE.
Spike the IV bag with the proper pump or gravity tubing
ADMINISTRATION
Take baseline vitals and document basic assessment.
Establish IV and mix medication.
Spike the bag of Soliris & prime line.
Infuse as ordered over 35-60 minutes.
Record vitals every 15 minutes and post infusion.
Record lot numbers and expiration dates for vials used.
Disconnect patient, flush line, and remove IV. Place pressure bandage at site.
Clean and dispose of used supplies.
ADDITIONAL INFO
Medication Guide: PDF Download