TEZSPIRE (SC)

tezepelumab-ekko

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Pharmacy specific orders / instructions always supersede the Agency guidance provided below. If in doubt, do not guess, call our office, or tag @TeamHelp-CareCoordination(Best Tag) and ask for Clinical Support.

ALWAYS establish IV access prior to mixing any meds

ALWAYS make sure you have everything you need to complete infusion before you begin

ALWAYS confirm your medication dose against the medication label and orders

ALWAYS reach out to us first (not the Pharmacy) with any questions

NEVER tell a Pt you have not given a particular medication before

MIXING

THIS MAY BE A PATIENT TEACH

(Confirm with Care Coordinator if patient teach or RN is to administer)

Obtain a clear/clean space to prepare the TEZSPIRE
Be sure all the necessary supplies are available to complete injection. You will need:
- Pre-filled pen or syringe, alcohol wipe, cotton ball or gauze, bandage, Sharps container
Allow TEZSPIRE to come to room temperature
Remove pre-filled pen or syringe from carton by grabbing the middle of the body
Check expiration date
Look at the liquid through the viewing window
- The liquid should be clear and colorless to light yellow
- There may be small air bubbles in the liquid; this is normal

ADMINISTRATION

Take baseline vitals and document basic assessment
Choose injection site
- Recommended injection site is front of thighs or lower part of abdomen
- Only a caregiver may inject in arm
Clean injection site with alcohol and let air dry
Start Injection
PREFILLED PEN
- Pull off cap by holding pre-filled pen body with 1 hand and pull cap straight off with other hand
- Inject TEZSPIRE by holding orange needle guard against the skin at a 90-degree angle
  - Make sure viewing window can be seen
- Press down firmly until orange needle guard cannot be seen
  - There will be a first ‘click’ that indicates injection has started
  - Orange plunger will move down in viewing window during injection
- Hold down firmly for about 15 seconds
  - There will be a second ‘click’ that indicates injection is finished
  - Orange plunder will fill viewing window
- After completion of injection, lift pre-filled pen straight up
  - Orange needle guard will slide down and lock into place over needle
- Check viewing window to make sure all medication has been injected
  - If the orange plunger does not fill the viewing window, the full dose has not been received, and healthcare provider must be contacted
PREFILLED SYRINGE
- Remove the needle cover
  - There may be a drop of liquid at the end of needle, and this is normal
- Gently pinch skin and administer subcutaneously at approximately 45-degree angle into recommended injection site
  - Inject all mediation by pushing in plunger all the way until plunger head is completely between the needle guard activation clips
- After injection, maintain pressure on plunger head and remove needle from skin
  - Release pressure on plunger head to allow needle guard to cover needle
Check injection site and gently hold pressure over skin with cotton ball or gauze until bleeding stopped
- Do not rub site
- Cover with bandage if needed
Monitor patient for any adverse reactions
Record vitals 5-10 minutes post infusion
Record lot number and expiration date
Clean and dispose of used supplies

ADDITIONAL INFO

HCP Website: Tezspire HCP

Prescribing Info: Tezspire PI

Administration Guide: Tezspire Administration;

For Patients: Tezspire Teaching Guide for Patients