**ALWAYS establish patent IV access and flush PRIOR to mixing medication**
Pharmacy specific orders / instructions always supersede the Agency guidance provided below. If in doubt, do not guess, call our office, or tag @TeamHelp-CareCoordination(Best Tag) and ask for Clinical Support.
ALWAYSÂ establish IV access prior to mixing any meds
ALWAYSÂ make sure you have everything you need to complete infusion before you begin
ALWAYSÂ confirm your medication dose against the medication label and orders
ALWAYSÂ reach out to us first (not the Pharmacy) with any questions
NEVERÂ tell a Pt you have not given a particular medication before
MIXING
Prior to mixing and administration, nurse must fill out the pre-infusion checklist on the TOUCH website.
Obtain a clear/clean space to prepare the Tysabri
Be sure all the necessary supplies are available to complete infusion from beginning to end. You will need IV start supplies, syringe, needle, and a bag of NS (usually 100ml), tubing (gravity tubing or pump tubing if using a pump)
Inspect the Tysabri vial for particulate material and discoloration prior to dilution
Withdraw 15ml of Tysabri from the vial using a sterile needle and syringe
Inject the concentrate into the 100ml bag of Normal Saline
Gently invert the Tysabri solution to mix completely. Do not shake
Allow solution to warm to room temperature
ADMINISTRATION
Take baseline vitals and document basic assessment
Spike the bag of Tysabri & prime line
Infuse the total volume over approximately 1 hour
Record vitals every 15 minutes after start of infusion AND then 5-10 minutes post infusion
Record lot numbers and expiration dates for vials used
Disconnect patient, flush line, and remove IV. Place pressure bandage at site
Clean and dispose of used supplies
ADDITIONAL INFO
Website: Dosing & Administration | TYSABRI® (natalizumab) HCP (tysabrihcp.com)
TOUCH Training Guide:
TOUCH Pre-infusion Checklist: