VIMIZIM (IV)

elosulfase alfa

ALWAYS establish patent IV access and flush PRIOR to mixing medication

ALWAYS establish IV access prior to mixing any meds

ALWAYS make sure you have everything you need to complete infusion before you begin

ALWAYS confirm your medication dose against the medication label and orders

ALWAYS reach out to us first (not the Pharmacy) with any questions

NEVER tell a Pt you have not given a particular medication befor

Obtain a clear/clean space to prepare the VIMIVZIM
Be sure all the necessary supplies are available to complete infusion from beginning to end
- You will need IV access supplies, iv tubing with a low-protein binding 0.2 micron in-line filter, syringe(s) and needle(s)
Determine the number of vials to be diluted based on the individual patient’s weight and the recommended dose of 2mg/kg
Withdraw and discard a volume of the 0.9% Sodium Chloride Injection, USP from the infusion bag equal to the volume of VIMIZIM concentrate to be added
Withdraw the VIMIZIM with a nonfiltered needle, the calculated volume from the appropriate number of vials
Add the calculated volume of VIMIIM to the infusion bag to a final volume of 100 ml or 250 ml
The final volume is based on the patient’s weight as follows:
- For patients who weigh less than 25 kg, the final volume should be 100 ml
- For patients who weigh 25 kg or more, the final volume should be 250 ml
The solution should be clear to slightly opalescent and colorless to pale yellow when diluted
- Note that a diluted solution with slight flocculation (e.g., thin translucent fibers) is acceptable for administration

Take baseline vitals and document basic assessment
For patients who weigh less than 25 kg:
- Initial infusion rate should be 3 mL per hour for the first 15 minutes
- If tolerated, increased to 6 mL per hour for the next 15 minutes
- If this rate is tolerated, then the rate may be increased every 15 minutes in 6 mL per hour increments, not to exceed 36 mL per hour
- The total volume of the infusion should be delivered over a minimum of 3.5 hours
For patients who weigh 25 kg or more:
- Initial infusion rate should be 6 mL per hour for the first 15 minutes
- If tolerated, the infusion rate may be increased to 12 mL per hour for the next 15 minutes
- If this rate is tolerated, then the rate may be increased every 15 minutes in 12 mL per hour increments, not to exceed 72 mL per hour
- The total volume of the infusion should be delivered over a minimum of 4.5 hours
Record vitals every 15 minutes for the first hour, then hourly AND 5-10 minutes post infusion
Record lot numbers and expiration dates for vials used
When infusion complete, add normal saline to the bag with MIMIZIM to flush residual VIMIIM solution from the entire tubing
Disconnect patient, flush line, and remove IV. Place pressure bandage at site
Clean and dispose of used supplies

HCP Website: Vimizimhcp

Prescribing Info: Vvimizim-Prescribing-Information

Resources for Patients: Vimizim-Resources-and-Support